![]() Therefore, it is recommended that lithium levels are carefully monitored and where necessary the lithium dosage is adjusted in patients receiving this combination. This may result in increased lithium toxicity, including increased risk of cardiotoxic and neurotoxic effects of lithium. In common with other diuretics, serum lithium levels may be increased when lithium is given concurrently with bumetanide. 4.5 Interaction with other medicinal products and other forms of interaction Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine. In patients with known hypersensitivity to sulfonamides or thiazides there may be a potential risk of hypersensitivity to bumetanide.īumetanide and/or amiloride found in urine by doping test is cause for disqualification of athletes. ![]() Careful monitoring of serum electrolytes and urea should be undertaken in these patients.Ĭaution is advised when used in patients with hypotension and in patients with porphyria.Ĭaution should be exercised when used in patients with hepatic impairment as there may be increased risk of encephalopathy. Hyponatraemia, hypochloraemia and raised blood urea may occur during vigorous diuresis especially in seriously ill patients. ![]() In common with other potent diuretics, Bumetanide/Amiloride 1mg/5mg Tablets should be used with caution in elderly patients or those with disorders rendering electrolyte balance precarious. Patients who are being treated with this preparation require regular supervision with monitoring of fluid and electrolyte status to avoid excessive fluid loss. It may be necessary to increase the dose of hypoglycaemic agents in diabetic patients.īumetanide/Amiloride 1mg/5mg Tablets should be used with caution in patients already receiving nephrotoxic or ototoxic drugs. The tablets may cause latent diabetes to become manifest. To minimise risk of hyperkalaemia, caution is advised if bumetanide/amiloride tablets are administered to patients with known/suspected diabetes mellitus (see section 4.5).īumetanide/Amiloride 1mg/5mg Tablets should be discontinued before a glucose tolerance test. Patients with prostatic hypertrophy or impaired micturition may be at risk of developing acute retention. Serum uric acid levels may be increased and acute attacks of gout may be precipitated.
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